Concern

Treatment for Wrinkles

Wrinkles are visible creases, folds, or ridges that develop in the skin as part of the natural aging process. Fine wrinkles measure less than 1 millimeter in width and depth, while coarse wrinkles measure 1 millimeter or more. As skin ages, collagen and elastin are lost, and their production decreases by approximately 1% each year. The dermis becomes thinner and loses its supportive network of fibers. Together with repeated facial expressions, gravity, sun exposure, and lifestyle factors, these changes create the permanent lines and folds associated with aging skin. The practical distinction is between dynamic lines, which appear when a muscle contracts and vanish when it relaxes, and static lines, which are etched into the dermis and remain visible at rest. A neuromodulator softens dynamic lines and does very little for static ones. The same injection can therefore satisfy one person and disappoint another, which is why identifying the kind of wrinkle comes first.

Medically reviewed by Dr. Kamakshi R. Zeidler, MD, FACS · Updated February 2026

At a Glance

Photoaging from UV exposure is responsible for approximately 90% of visible changes to the skin[3]
Collagen and elastin synthesis decreases by approximately 1% each year as skin ages[7]
Fine wrinkles are less than 1 mm in width and depth, while coarse wrinkles are 1 mm or more[7]
Botulinum toxin injection has been shown to be more effective than placebo at improving wrinkles for up to 120 days[5]
Visible signs of skin aging may begin to appear after age 25[3]

Signs & symptoms

  • Fine lines appearing around the eyes (crow's feet)
  • Horizontal lines across the forehead
  • Vertical lines between the eyebrows ("eleven" lines, frown lines or glabellar lines)
  • Lines extending from the corners of the mouth (marionette lines)
  • Creases running from the nose to mouth corners (nasolabial folds)
  • Thin, less resilient skin texture
  • Loss of skin elasticity and firmness
  • Skin appearing looser or more saggy

What causes Wrinkles

  • Decreased collagen and elastin production with age
  • Slower skin cell division causing dermis thinning
  • Repeated facial muscle contractions from expressions
  • Loss of collagen and elastin from photoaging due to cumulative UV radiation exposure
  • Reduced skin moisture retention capacity
  • Decreased oil gland secretion

Risk factors

  • Age (most common in those over 40, visible changes may begin after age 25)
  • Sun exposure and UV radiation (responsible for approximately 90% of visible skin aging)
  • Smoking and tobacco use
  • Fair or light skin tone
  • Genetic predisposition to skin aging
  • Low body mass index
  • Chronic dehydration
  • Poor nutrition
  • High stress levels
  • Air pollution exposure

How it's assessed

  1. Visual examination of the affected skin
  2. Assessment of wrinkle depth and location
  3. Skin texture and elasticity evaluation
  4. Review of sun exposure history
  5. Evaluation of skin hydration levels
  6. Assessment of lifestyle factors affecting skin health

How are Wrinkles treated

Several approaches can address wrinkles:

Curious what's possible?

Schedule a consultation to explore what's right for you.

Recovery & outlook

  • Wrinkles are a natural part of aging and cannot be completely prevented
  • Consistent sun protection, lifestyle modifications, and appropriate skincare may slow the development of new wrinkles
  • Treatment results vary based on wrinkle severity and type
  • Many treatments require ongoing maintenance for sustained results
  • Combination approaches often yield the most noticeable improvements

Frequently Asked Questions

  • Wrinkles are visible creases or folds that develop as part of the natural aging process. With age, skin cells divide more slowly, the dermis thins, and the network of collagen and elastin fibers loosens. Repeated facial expressions, gravity, and sun exposure also contribute to the permanent lines and folds that form in the skin.
  • The earliest signs typically include fine lines around the eyes, horizontal forehead lines, frown lines of the glabella, and subtle creases that appear with facial expressions. These changes may begin after age 25, but they become more prominent with age and sun exposure.
  • Wrinkles develop through several factors. Natural aging reduces collagen and elastin production by about 1% per year, while sun exposure causes approximately 90% of visible skin aging. Smoking, repeated facial expressions, genetics, dehydration, and poor nutrition also contribute.
  • See a dermatologist if you want a professional evaluation of cosmetic treatment options, are interested in prescription-strength products such as retinoids, or notice unusual skin changes accompanying wrinkles. A clinical evaluation can match treatment options to your skin type, wrinkle severity, and cosmetic goals.
  • Treatment options range from topical products to in-office procedures. Over-the-counter choices include retinol, moisturizers, and peptides. Professional treatments include botulinum toxin injections for expression lines, dermal fillers for volume loss, chemical peels, laser resurfacing, and microneedling. A clinical evaluation can determine which approach is most appropriate.
  • Wrinkles cannot be completely prevented, but their development can be slowed. Dermatologists recommend daily sun protection with SPF 30 or higher, avoiding smoking, staying hydrated, eating a balanced diet rich in fruits and vegetables, and using products that contain retinoids. Beginning these protective measures early may help delay visible aging.
  • Recovery depends on the treatment. Botulinum toxin injections require no recovery time. Microneedling and dermal fillers typically require one to three days, while chemical peels, dermabrasion, and laser resurfacing may require one to three weeks depending on treatment intensity.
  • Botox and Daxxify are both botulinum toxin type A, and both relax the muscles that fold the skin into dynamic lines. Daxxify uses a peptide carrier instead of human serum albumin, and its published duration runs longer for many patients. That difference changes the treatment interval, annual cost, and number of appointments. Duration also varies by person, dose, and the muscle being treated. The practical way to choose is to try one and count the weeks until movement returns. We carry both, so switching is a conversation with us rather than a referral elsewhere.
  • Yes, particularly static wrinkles, which are the kind injections address least well. Etched lines are a dermal problem. Fractional laser treatment, a deeper chemical peel, and microneedling reach the dermis by injuring the skin in a controlled way, prompting it to rebuild collagen as it heals. The trade is downtime, which scales with treatment depth. A light treatment costs a weekend and produces a modest change, while a croton oil peel involves a couple of weeks of visible healing and does considerably more. We offer Halo, ProFractional, microneedling, and a croton oil peel across our offices in Campbell, Menlo Park, Greenbrae, and Walnut Creek. The depth we choose is matched to the downtime you can realistically give it.
Board-Certified Specialists

Your Physicians

Dr. Kamakshi R. Zeidler

Dr. Kamakshi Zeidler

MD, FACS

Dr. Dino Elyassnia

Dr. Dino Elyassnia

MD, FACS

Dr. Jane Weston

Dr. Jane Weston

MD, FACS

Dr. Bao Tran

Dr. Bao Tran

MD

Dr. Shirley Liu

Dr. Shirley Liu

MD, MHS

Dr. Michele Koo

Dr. Michele Koo

MD, FACS

Dr. Rick Lehman

Dr. Rick Lehman

MD, FACS

Dr. Jean Gillon

Dr. Jean Gillon

MD, FACS

Dr. Amelia K. Hausauer

Dr. Amelia Hausauer

MD, FAAD

9 board-certified physicians · 4 locations

Medically reviewed by Dr. Kamakshi R. Zeidler, MD, FACS · Last reviewed: 2026-09-01